دانلود کتاب خارجی - دانلود رایگان کتاب لاتین PDF علمی

تعداد نتایج: 2497

The Sense of Silence

By Andrea Pirringer
Publisher: neobooks, 2014-09-29
Pages: 41
Language: de
ISBN_13:9783847614319
ISBN_10:3847614312
Subject: Religion

Entspannt Mutter sein

Gelassener mit den Anforderungen des Alltags und den eigenen...

جزئیات و درخواست

By Annemarie Pfeifer
Publisher: Gerth Medien, 2018-02-26
Pages: 136
Language: de
ISBN_13:9783961223190
ISBN_10:396122319X
Subject: Family & Relationships

Phänomen Nahtod

Faszinierende Entdeckungen eines Psychiaters

جزئیات و درخواست

By Walter Meili
Publisher: SCM Hänssler, 2016-08-04
Pages: 242
Language: de
ISBN_13:9783775173537
ISBN_10:3775173536
Subject: Religion

Handbuch Seelsorge

Zusammengestellt vom "Arbeitskreis Seelsorge" im BFP unter d...

جزئیات و درخواست

By Dietmar Schwabe
Publisher: Forum Theologie & Gemeinde, 2019-05-04
Pages: 167
Language: de
ISBN_13:9783942001137
ISBN_10:3942001136
Subject: Religion

Escaping the Matrix

Setting Your Mind Free to Experience Real Life in Christ

جزئیات و درخواست

By Gregory A. Boyd, Al Larson
Publisher: Baker Books, 2005-04-01
Pages: 224
Language: en
ISBN_13:9781441201379
ISBN_10:1441201378
Subject: Religion

Lori Hersberger : New Roots and Paintings

ausstellung im Museum für Gegenwartskunst der Offetlichen Ku...

جزئیات و درخواست

By Lori Hersberger, Marianne Wackernagel
2001
Pages: 70
Language: de
OTHER:UCSD:31822037372646
Subject: Installations (Art)

End Stage Therapy and Heart Transplantation

جزئیات و درخواست

Publisher: BoD – Books on Demand, 2024-04-18
Pages: 150
Language: en
ISBN_13:9780850141719
ISBN_10:0850141710
Subject: Medical

Social Networking and Community Behavior Modeling: Qualitative and Quantitative Measures

Qualitative and Quantitative Measures

جزئیات و درخواست

By Safar, Maytham
Publisher: IGI Global, 2011-12-31
Pages: 401
Language: en
ISBN_13:9781613504451
ISBN_10:1613504454
Subject: Computers

Medicinal Plants

Biodiversity and Drugs

جزئیات و درخواست

By M. K. Rai, Geoffrey A. Cordell, Jose L. Martinez, Mariela Marinoff, Luca Rastrelli
Publisher: CRC Press, 2012-07-03
Pages: 716
Language: en
ISBN_13:9781578087938
ISBN_10:1578087937
Subject: Health & Fitness

Body Composition Changes and Nutrition Therapy in Surgical Oncology Patients

جزئیات و درخواست

By Shanjun Tan, Guohao Wu, Luca Gianotti
Publisher: Frontiers Media SA, 2024-02-23
Pages: 138
Language: en
ISBN_13:9782832545195
ISBN_10:283254519X
Subject: Medical

Heart Failure: From Research to Clinical Practice

Volume 3

جزئیات و درخواست

By Md. Shahidul Islam
Publisher: Springer, 2018-05-14
Pages: 408
Language: en
ISBN_13:9783319782805
ISBN_10:3319782800
Subject: Medical

Resolution Pharmacology - Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies

$In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.$

جزئیات و درخواست

By Mauro Perretti, Trinidad Montero-Melendez, Lucy V. Norling
Publisher: Frontiers Media SA, 2019-11-04
Pages: 205
Language: en
ISBN_13:9782889630844
ISBN_10:2889630846

Flash Art

جزئیات و درخواست

2003
Pages: 416
Language: en
OTHER:UOM:39015058310148
Subject: Art

Official Gazette of the United States Patent and Trademark Office

Patents

Free Epub

جزئیات و درخواست

1999
Pages: 1540
Language: en
OTHER:PSU:000043037568
Subject: Patents

Clinical Virology Manual

جزئیات و درخواست

By Richard L. Hodinka, Stephen A. Young, Benjamin A. Pinksy
Publisher: John Wiley & Sons, 2020-07-10
Pages: 639
Language: en
ISBN_13:9781555819156
ISBN_10:155581915X
Subject: Medical

Index Medicus

Free Epub

جزئیات و درخواست

2004
Pages: 1504
Language: en
OTHER:MINN:31951P00992541Q
Subject: Medicine

River Flow ...

Proceedings of the International Conference on Fluvial Hydra...

جزئیات و درخواست

2002
Pages: 738
Language: en
OTHER:UOM:39015056819447
Subject: Alluvium

Public Spaces

Times of Crisis and Change

جزئیات و درخواست

By Joao Teixeira Lopes, Ray Hutchison
Publisher: Emerald Group Publishing, 2016-11-17
Pages: 434
Language: en
ISBN_13:9781786354631
ISBN_10:1786354632
Subject: Social Science

Lipoxygenases in Inflammation

جزئیات و درخواست

By Dieter Steinhilber
Publisher: Springer, 2016-04-27
Pages: 252
Language: en
ISBN_13:9783319277660
ISBN_10:3319277669
Subject: Medical

Art ... Basel

The Art Show

جزئیات و درخواست

2010
Pages: 754
Language: en
OTHER:STANFORD:36105133538608
Subject: Art

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