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تعداد نتایج: 1477

Computational Approaches to Nuclear Receptors

$Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several "omics" projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors.$

جزئیات و درخواست

By Pietro Cozzini, Glen E. Kellogg
Publisher: Royal Society of Chemistry, 2012
Pages: 191
Language: en
ISBN_13:9781849733649
ISBN_10:1849733643
Subject: Medical

Nuclear Receptors

The Art and Science of Modulator Design and Discovery

جزئیات و درخواست

By Mostafa Z. Badr
Publisher: Springer Nature, 2021-09-28
Pages: 676
Language: en
ISBN_13:9783030783150
ISBN_10:3030783154
Subject: Medical

The Pharmacology of Taste

جزئیات و درخواست

By R. Kyle Palmer, Guy Servant
Publisher: Springer Nature, 2022-06-13
Pages: 357
Language: en
ISBN_13:9783031064500
ISBN_10:303106450X
Subject: Medical

Cocoa, Chocolate and Human Health

جزئیات و درخواست

By Sabine Ellinger, Benno F. Zimmermann
Publisher: MDPI, 2020-05-23
Pages: 288
Language: en
ISBN_13:9783039285884
ISBN_10:3039285882
Subject: Science

Computational Toxicology

Methods and Protocols

جزئیات و درخواست

By Orazio Nicolotti
Publisher: Springer Nature,
Pages: 441
Language: en
ISBN_13:9781071640036
ISBN_10:1071640038

Physico-chemical and Computational Approaches to Drug Discovery

جزئیات و درخواست

By Javier Luque, Xavier Barril
Publisher: Royal Society of Chemistry, 2012
Pages: 443
Language: en
ISBN_13:9781849733533
ISBN_10:1849733538
Subject: Medical

Frontiers in Drug Design and Discovery

جزئیات و درخواست

By Atta-ur- Rahman, Gary W. Caldwell, M. Iqbal Choudhary, Mark R. Player
Publisher: Bentham Science Publishers, 2010-12-13
Pages: 644
Language: en
ISBN_13:9781608052011
ISBN_10:160805201X
Subject: Medical

In Silico Drug Discovery and Design

Theory, Methods, Challenges, and Applications

جزئیات و درخواست

By Claudio N. Cavasotto
Publisher: CRC Press, 2015-08-06
Pages: 539
Language: en
ISBN_13:9781482217858
ISBN_10:1482217856
Subject: Medical

Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set

جزئیات و درخواست

Publisher: John Wiley & Sons, 2021-04-20
Pages: 6057
Language: en
ISBN_13:9781119530305
ISBN_10:111953030X
Subject: Science

Journal

جزئیات و درخواست

By American Chemical Society
2004
Pages: 858
Language: en
OTHER:NYPL:33433068514599
Subject: Chemistry

Ethical Eating

A Complete Guide to Sustainable Food

جزئیات و درخواست

By Malcolm Coxall
Publisher: Malcolm Coxall, Cornelio Books, 2014-02-20
Pages: 774
Language: en
ISBN_13:9788494178313
ISBN_10:8494178318
Subject: Social Science

Bote für Tirol und Vorarlberg

Free Epub

جزئیات و درخواست

By Tirol
1854
Pages: 1028
Language: de
OTHER:ONB:+Z227627708

Governing Digitally Integrated Genetic Resources, Data, and Literature

Global Intellectual Property Strategies for a Redesigned Mic...

جزئیات و درخواست

By Jerome H. Reichman, Paul F. Uhlir, Tom Dedeurwaerdere
Publisher: Cambridge University Press, 2016-05-19
Pages: 679
Language: en
ISBN_13:9781316380994
ISBN_10:1316380998
Subject: Law

Molecular Docking for Computer-Aided Drug Design

Fundamentals, Techniques, Resources and Applications

جزئیات و درخواست

By Mohane S. Coumar
Publisher: Academic Press, 2021-02-17
Pages: 522
Language: en
ISBN_13:9780128223130
ISBN_10:0128223138
Subject: Medical

Bioactive Peptides from Food

Sources, Analysis, and Functions

$A growing body of scientific evidence has revealed that many food peptides exhibit specific biological activities in addition to their established nutritional value. Bioactive peptides present in foods may help reduce the worldwide epidemic of chronic diseases that account for a great number of premature deaths annually. Bioactive peptides can be defined as isolated small fragments of proteins which provide some physiological health benefits. They act as potential modifiers reducing the risk of many chronic diseases. Bioactive Peptides from Food: Sources, Analysis, and Functions considers fundamental concepts, sources, hydrolysis, fractionation, purification, analysis, chemical synthesis, functions, and regulatory status of nutraceutical bioactive peptides. Methods of isolation of these peptides from different protein sources with their in vitro and vivo physiological effects are addressed. Divided into seven sections, this book delves into how these peptides play a major role in the development of various functional foods. Numerous bioactive peptides have been reported in recent years as naturally present or generated from food proteins of different origins like milk, eggs, soya, fish, and meat. Key Features: Includes a detailed study of the different sources of bioactive peptides Discusses the health benefits, such as antimicrobial, antiallergic, antihypertensive, antitumor, and immunomodulatory properties of peptides Explorates the state of the art analysis methods of peptides Discovers the bioinformatics of possible bioactive peptides Written by experts in their field from around the world, Bioactive Peptides from Food reveals the world of databases of peptides. It is a great resource for food scientists, technologists, chemists, nutrition researchers, producers, and processors working in the whole food science and technology field as well as those who are interested in the development of innovative functional products.$

جزئیات و درخواست

By Leo M.L. Nollet, Semih Ötleş
Publisher: CRC Press, 2022-03-28
Pages: 553
Language: en
ISBN_13:9781000551938
ISBN_10:1000551938
Subject: Technology & Engineering

Declarative Logic Programming

Theory, Systems, and Applications

جزئیات و درخواست

By Michael Kifer, Yanhong Annie Liu
Publisher: Morgan & Claypool, 2018-09-19
Pages: 617
Language: en
ISBN_13:9781970001976
ISBN_10:1970001976
Subject: Computers

Caso funesto occorso tra sbirri e scolari (e altri misfatti)

Padova 15 febraro 1723

جزئیات و درخواست

By Ruggero Soffiato
Publisher: FrancoAngeli, 2024-05-10T00:00:00+02:00
Pages: 187
Language: it
ISBN_13:9788835165125
ISBN_10:8835165121
Subject: History

Bollettino ufficiale delle nomine, promozioni e destinazioni negli ufficiali e sottufficiali del R. esercito italiano e nel personale dell'amministrazione militare

Free Epub

جزئیات و درخواست

1935
Pages: 2192
Language: it
OTHER:IBNR:CR300101909

Annuario generale d'Italia guida generale del Regno

Free Epub

جزئیات و درخواست

Pages: 2276
Language: it
OTHER:IBNR:CR300055590

Directory of Graduate Research

جزئیات و درخواست

By American Chemical Society. Committee on Professional Training
2005
Pages: 1932
Language: en
OTHER:UCSD:31822036045805
Subject: Biochemistry

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