دانلود کتاب خارجی - دانلود رایگان کتاب لاتین PDF علمی

تعداد نتایج: 1950

Researches on New Generation Tumor Markers

جزئیات و درخواست

By Yildiz Dincer, Ph.d.
2019-02-22
Pages: 339
Language: en
ISBN_10:1536143677
ISBN_13:9781536143676

Kleintieronkologie

Diagnose und Therapie von Tumorerkrankungen bei Hund und Kat...

جزئیات و درخواست

By Martin Kessler
Publisher: Georg Thieme Verlag, 2022-07-06
Pages: 3109
Language: de
ISBN_13:9783132419278
ISBN_10:3132419273
Subject: Medical

Klinische Chemie und Hämatologie

Biomedizinische Analytik für MTLA und Studium

جزئیات و درخواست

By Jürgen Hallbach
Publisher: Georg Thieme Verlag, 2019-04-10
Pages: 529
Language: de
ISBN_13:9783132417991
ISBN_10:3132417998
Subject: Medical

Uroonkologie kompakt

Diagnostik und Therapie

جزئیات و درخواست

By Peter Albers
Publisher: Georg Thieme Verlag, 2017-08-30
Pages: 245
Language: de
ISBN_13:9783794568796
ISBN_10:3794568796
Subject: Medical

Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2)

جزئیات و درخواست

By Joseph Loscalzo, Anthony S. Fauci, Dennis L. Kasper, Stephen Hauser, Dan Longo
Publisher: McGraw Hill Professional, 2022-04-05
Pages: 4132
Language: en
ISBN_13:9781264268511
ISBN_10:1264268513
Subject: Medical

Characterizing Plasma Ultrashort Single-Stranded Cell-Free DNA in Non-Small Cell Lung Carcinoma

جزئیات و درخواست

By Jordan C Cheng
2023
Language: en
OTHER:OCLC:1395978619

Zur Geschichte der Gynäkologie und Geburtshilfe

Aus Anlaß des 100jährigen Bestehens der Deutschen Gesellscha...

جزئیات و درخواست

By Lutwin Beck
Publisher: Springer-Verlag, 2013-03-07
Pages: 402
Language: de
ISBN_13:9783642710926
ISBN_10:3642710921
Subject: Medical

Lab-on-Chips for Capture, Detection, and Isolation of Cancerous Extracellular Vesicles

$Cancer is a group of diseases involving abnormal growth of cells with a potential to spread to the other parts of the body. It is predicted that one in two will be diagnosed with Cancer by 2030 and one in four would die. The continuous growth and metastasis of cancer cells depend upon cell-to-cell communication. This communication largely involves the secretion of soluble factors by cancer cells within the tumor microenvironment, although these cell types have also shown to export membrane-encapsulated particles containing regulatory molecules that contribute to cell-to-cell communication. These particles are known as extracellular vesicles (EVs) and include exosomes and microvesicles. EVs are a group of extracellular communication organelles enclosed by a phospholipid bilayer secreted by all types of cells throughout the animal kingdom. These vesicles are in the range of 30 to 1000 nm containing a myriad of substances like RNA, DNA, proteins, and lipids from their origin cells, offering a good source of biomarkers. Although their characteristics provide EVs great potential as biomarkers, efficient isolation and detection techniques are still challenging. Currently, the standard method for their isolation and quantification from body fluids is by ultracentrifugation, which is not a practical method to be implemented in a clinical setting. Thus, a versatile and cutting-edge platform is required to detect and isolate exosomes selectively for further analysis at a clinical level. This dissertation is focused on developing lab-on-chip devices for the capture, detection, and isolation of cancerous extracellular vesicles from MCF7 (breast cancer cell lines) culture media. Here, we have explored three platforms based on gold nanoparticles, namely, in-situ synthesized nanocomposites, gold nano-islands on a substrate, and colloidal platform with suspended gold nanoparticles (AuNPs). The first step was to identify the suitable platform for the capture and isolation of EVs, based on the sensitivity of the platform. Initially, gold - poly (dimethylsiloxane) (PDMS) nanocomposites, were created by the in-situ synthesis of nanoparticles on the surface of PDMS substrate by reducing gold precursor solution with curing agent of PDMS. The Au-PDMS nanocomposites are a special category of composites, with gold nanoparticles segregated in a sub-surface layer of the polymer. The second platform is the gold nano-island platform, where AuNPs are synthesized using Turkevich's method and then deposited on a glass substrate by thermal convection. Then, the deposited nanoparticles are heat-treated at 560°C for an hour to form gold nano-islands. The refractive index sensitivity of nanocomposite and gold nano-islands is found to be around 50 and 111nm/RIU, respectively. The lower sensitivity in the nanocomposites as the nanoparticles are under the surface covered by a thin PDMS layer, whereas the in case of gold nanoislands, they are above the surface and available to interact directly with the analyte. Considering the sensitivities, the gold nano-island platform was utilized further for the capture and detection of EVs. The gold nano-islands on a substrate platform, where only half of the islands are available for sensing and capture, exhibited a better sensitivity meaning that utilizing the whole surface of nanoparticle would result in even better sensitivity as in the case of the third platform where gold nanoparticles suspended in a colloidal solution. This dissertation then focuses on the biosensing protocol developed based on localized surface plasmon resonance (LSPR) of gold nano-islands, for the detection of EVs. The protocol involves the adsorption or binding of multiple bio-entities to the gold nano-island and absorption spectrum measurement after each step. The molecular interactions shift the gold plasmon band in the visible spectrum toward longer wavelengths and the shift is proportional to the concentration of the entity. The sensing protocol utilizes the strong affinity between EVs, and polypeptide called Venceremin or Vn96, which is specifically designed to capture EVs by binding the heat shock proteins (HSPs) present on their surface. Physical modeling, based on the characteristics of the gold nano-islands and the bio-entities involved in the sensing, is developed to determine the detection capability of the platform, which is optimized experimentally at each stage of the sensing protocol. The results and modeling present a relationship between the plasmonic shift and the concentration of exosomes. Further, a simple microfluidic device is designed for detecting EVs consists of a glass substrate with gold nano-islands, sealed by a PDMS film that contains a microchannel with a collection chamber in between. The same biosensing protocol has been transferred to a microfluidic environment by infusing biosensing entities into the device and measurement of the spectrum after each step. The capture and detection ability of the device is validated by Atomic Force Microscopy (AFM) and the measurement of gene copy numbers using droplet digital PCR (ddPCR). The results indicate that the developed device can capture and isolate the EVs from a very low sample volume, in less than 30 minutes, without affecting their size and shape, a major advantage compared to existing methods. Later, to increase the sensitivity, a two-level microfluidic device is fabricated utilizing a double-sided gold nano-island substrate, where AuNPs are deposited on both sides. This technique can be extended to multi-level microfluidics by introducing an intermediate channel in between the nanoisland substrates. Parallelly, the gold nanoparticles suspended in a colloidal solution were utilized for the capture, detection, and isolation of EVs using the same protocol. Initially, this technique was studied at the cuvette stage by mixing the desired volume and concentrations of bio-entities manually and measuring the absorption spectrum at each stage for LSPR shift. As the nanoparticles are freely suspended in the solution, the binding of EVs on the entire surface area contributes the nanoparticles to sediment at the bottom of the cuvette. Thus, the precipitation method was used to isolate EVs. Then, a liquid biopsy chip is designed and fabricated using soft-lithography consisting of a 3D mixer, a collection chamber, and gravity assisted sedimentation unit. The streptavidin-coated magnetic particles are utilized in the liquid biopsy chip for the isolation of EVs. The device consists of a 3D mixer to ensure capture efficiency and it also consists of a sedimentation unit, which allows EV-captured magnetic particles to settle in it. The sedimented EV-captured magnetic particles are then isolated from the chip for elution of EVs and their validation using Nanoparticle Tracking Analysis (NTA), AFM, and gene amplification. The results clearly show that the proposed liquid biopsy chip can isolate the EVs without affecting their morphology. Thus, this chip can be considered as a potential point-of-care device for diagnostics in a clinical setting and for the isolation of EVs for future therapeutics.$

جزئیات و درخواست

By Srinivas Bathini
2021
Language: en
OTHER:OCLC:1393266937

Management of Orthopaedic Infections

A Practical Guide

$An evidence-based resource for effectively managing challenging orthopaedic infections Orthopaedic infections represent common, potentially devastating, and sometimes fatal complications that can occur after any surgery. Infections associated with orthopaedic trauma are especially prevalent, and there is an increasing incidence of bone infections linked to a greater number of joint arthroplasties being performed annually. Management of Orthopaedic Infections: A Practical Guide by renowned orthopaedic surgeon and researcher Antonia Chen is a practical clinical reference to assist clinicians in the diagnosis and treatment of challenging infections spanning the entire orthopaedic specialty. The step-by-step guide covers frequent organisms found in orthopaedics, molecular methods to improve organism determination, different antibiotic formulations to treat infections, various irrigation solutions used during surgery, and surgical dressings. Ten concise chapters cover surgical management of common infectious pathologies, including osteomyelitis, septic joint, periprosthetic joint infection, open fractures and infected nonunions, spine infections, and graft infections. Key Features High-quality figures and instructional surgical videos illustrate and enhance understanding of important concepts Multiple tables provide quick references and easy access to salient information needed to manage the care of patients with orthopaedic infections Practical tips from clinicians with vast expertise inform optimal treatment strategies and enable improved outcomes This is a must-have pocket resource for medical students, residents, fellows, and practitioners in orthopaedic surgery, as well as allied health personnel.$

جزئیات و درخواست

By Antonia F. Chen
Publisher: Thieme, 2021-04-22
Pages: 352
Language: en
ISBN_13:9781684201341
ISBN_10:1684201349
Subject: Medical

Color Atlas of Genetics

جزئیات و درخواست

By Eberhard Passarge
Publisher: Thieme, 2017-12-13
Pages: 721
Language: en
ISBN_13:9783132580022
ISBN_10:3132580023
Subject: Medical

Materials Science and Applied Chemistry

جزئیات و درخواست

By Valdis Kokars
Publisher: Trans Tech Publications Ltd, 2018-02-05
Pages: 432
Language: en
ISBN_13:9783035732382
ISBN_10:3035732388
Subject: Technology & Engineering

The Surgical Word Book

جزئیات و درخواست

By Claudia J. Tessier
Publisher: Saunders, 2004
Pages: 2376
Language: en
OTHER:PSU:000055980586
Subject: Medical

Regulatory Gut Peptides in Paediatric Gastroenterology and Nutrition

6th Annual Meeting of the GPGE, Goldegg/Salzburg, May 1-4, 1...

جزئیات و درخواست

By Gesellschaft für Pädiatrische Gastroenterologie und Ernährung. Meeting
1992
Pages: 412
Language: en
OTHER:UOM:39015036548116
Subject: Digestive organs

By Michael Swash, Martin S. Schwartz
Publisher: Springer, 1984
Pages: 224
Language: en
OTHER:UOM:39015009571111
Subject: Medical

Circulating Tumor Cells

Isolation and Analysis

جزئیات و درخواست

By Z. Hugh Fan
Publisher: Wiley, 2016-04-18
Pages: 488
Language: en
ISBN_10:1118915534
ISBN_13:9781118915530
Subject: Science

Laposata's Laboratory Medicine Diagnosis of Disease in Clinical Laboratory Third Edition

جزئیات و درخواست

By Michael Laposata
Publisher: McGraw Hill Professional, 2019-01-04
Pages: 592
Language: en
ISBN_13:9781260116809
ISBN_10:1260116808
Subject: Medical

ICD-9-CM for Hospitals Compact Professional for Hospitals

جزئیات و درخواست

By Bardes, Ingenix, Shelley, Schmidt
Publisher: Delmar Thomson Learning, 2005-09
Pages: 1798
Language: en
ISBN_10:1563377020
ISBN_13:9781563377020
Subject: Business & Economics

Fishman's Pulmonary Diseases and Disorders, 2-Volume Set, Sixth Edition

جزئیات و درخواست

By Michael A. Grippi, Danielle E. Antin-Ozerkis, Charles S. Dela Cruz, Robert Kotloff, Camille N. Kotton
Publisher: McGraw Hill Professional, 2022-10-22
Pages: 2773
Language: en
ISBN_13:9781260474060
ISBN_10:1260474062
Subject: Medical

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