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تعداد نتایج: 249

Genetic Toxicology of Complex Mixtures

By Michael D. Waters, F.Bernhard Daniel, Joellen Lewtas, Martha M. Moore, Stephen Nesnow
Publisher: Springer Science & Business Media, 2013-03-13
Pages: 368
Language: en
ISBN_13:9781468458503
ISBN_10:1468458507
Subject: Medical

Genetic Toxicology

جزئیات و درخواست

By Albert P. Li
Publisher: CRC Press, 1991-03-27
Pages: 508
Language: en
ISBN_10:0849388155
ISBN_13:9780849388156
Subject: Medical

Genotoxicity of Complex Chemical Mixtures

$Complex chemical mixtures are ubiquitous in the environment. Humans are frequently exposed to these mixtures; therefore, it is important to understand potential interactions of chemical mixtures. Mixture interactions may influence the absorption, distribution, metabolism or excretion of the components of a complex mixture. The research conducted for this dissertation has coupled chemical fractionation with in vitro and in vivo bioassays to assess the potential carcinogenic risk of complex mixtures. A non-aqueous phase liquid from a wood treatment plant was separated into acid (AF), base (BF) and neutral fractions (NF). The NF was further enriched using column chromatography to produce a polychlorinated dinbenzo-p-dioxin (PCDD) and a polycyclic aromatic hydrocarbon (PAH) fraction. The genotoxicity of these mixtures were assessed via analytical quantification, in vitro (Salmonella microsome and E. coli prophage induction) and in vivo (32P-postlabeling) bioassays. The NF was further tested to measure bulky DNA adducts and induction of tumor formation. The AF contained the highest level of pentachlorophenol and the highest concentration of total PAHs. Although the carcinogenic PAHs were highest in the PCDD fraction, the highest concentrations of benzo(a)pyrene (BAP), indeno(1,2,3-cd)pyrene and dibenz(a, h)anthracene were detected in the PAH fraction. A positive genotoxic response in Salmonella was induced by the crude extract, the PAH and BF, whereas the AF and BF induced a positive response in the E. coli assay. In vivo, the PAH fraction induced the highest DNA adduct frequencies in the lung. The NF, reconstituted mixture (RM) (which includes equivalent concentrations of seven carcinogenic PAHs in the NF), BAP and the NF amended with BAP (NF+BAP) were all tested in an infant mouse model. At the highest dose, after a 24 hr exposure, NF+BAP had the highest total DNA adducts measured in liver which was three to seven times higher than with other treatments. Adduct levels were comparable to the control after 280 days. The highest incidence of tumors was observed in the liver. At the high dose, NF+BAP elicited the highest incidence of tumors. The results of this research confirm previous studies and indicate that the carcinogenic potential of PAH mixtures may be greater than predicted by chemical analysis.$

جزئیات و درخواست

By Tracie Denise Phillips
2010
Language: en
OTHER:OCLC:610027220

Applicability of Bacterial Short-term Tests in the Assessment of Genetic Toxicity of Complex Mixtures

جزئیات و درخواست

By Lars Nylund
1994
Pages: 78
Language: en
ISBN_10:9518020264
ISBN_13:9789518020267

Genotoxicity of Complex Mixtures

CHO Cell Mutagenicity Assay

جزئیات و درخواست

1985
Language: en
OTHER:OCLC:52244641

Environmental Toxicity of Complex Chemical Mixtures

جزئیات و درخواست

By Annika Margaret Gillespie
2010
Language: en
OTHER:OCLC:609447550

Methods for Assessing the Effects of Mixtures of Chemicals

جزئیات و درخواست

By Velimir B. Vouk
Publisher: John Wiley & Sons, 1987
Pages: 936
Language: en
OTHER:UCSD:31822002420156
Subject: Biological monitoring

Genotoxicity of Model and Complex Mixtures of Polycyclic Aromatic Hydrocarbons

$Polycyclic aromatic hydrocarbons (PAHs) are one of the most ubiquitous classes of environmental carcinogens; however, limited information is available to describe their potential genotoxic interactions. This manuscript reports on the interactions of PAHs in complex mixtures as determined in microbial mutagenicity assays. Samples analyzed included separate 2-, 3-, and 4-ring PAH individual model fractions (IMFs) constructed to simulate the composition of a model coal tar. These were tested individually and in various combinations, including a reconstituted model fraction (RMF) composed of all three IMFs. A solvent extract of coal tar and a benzo(a)pyrene-amended extract of coal tar were also tested. The maximum mutagenic response of 1,089 revenants was induced by the RMF at a dose of 90 ?g/plate with metabolic activation. At the four lowest dose levels, the response observed in the RMF sample was increased when compared to the 4-ring-IMF sample alone. However, the response observed with the RMF sample at the highest dose tested (900 ?g/plate) was less than was observed in the 4-ring-IMF sample tested independently. When IMF samples were combined or mixed with individual chemicals, some inhibition was observed. These data indicate that mixtures of PAHs can exhibit a variety of mutagenic interactions controlled by both the metabolism of the PAHs and by their concentration in the mixture. This research was supported by NIEHS Grant No. P42-ES04917.$

جزئیات و درخواست

By SL. Collie, KC. Donnelly, HJ. Huebner, AM. Onufrock, TD. Phillips
1996
Pages: 11
Language: en
OTHER:OCLC:1251667277
Subject: Coal-tar

Comparative Potency of Complex Mixtures

Use of Short-term Genetic Bioassays in Cancer Risk Assessmen...

جزئیات و درخواست

By Joellen Lewtas, Health Effects Research Laboratory (Research Triangle Park, N.C.)
1985
Pages: 14
Language: en
OTHER:OCLC:17995577
Subject: Genetic toxicology

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III

جزئیات و درخواست

By Michael D. Waters
Publisher: Springer Science & Business Media, 2012-12-06
Pages: 580
Language: en
ISBN_13:9781461336112
ISBN_10:1461336112
Subject: Science

Methods for Genetic Risk Assessment

جزئیات و درخواست

By David Brusick
Publisher: CRC Press, 1994-01-11
Pages: 274
Language: en
ISBN_10:1566700396
ISBN_13:9781566700399
Subject: Science

Current Catalog

Free Epub

جزئیات و درخواست

By National Library of Medicine (U.S.)
1991
Pages: 700
Language: en
OTHER:UOM:39015046741198
Subject: Medicine

National Library of Medicine Current Catalog

Cumulative listing

Free Epub

جزئیات و درخواست

By National Library of Medicine (U.S.)
1991
Pages: 1068
Language: en
OTHER:MINN:31951D00419043U
Subject: Medicine

Principles of Genetic Toxicology

جزئیات و درخواست

By David Brusick
Publisher: Springer Science & Business Media, 2012-12-06
Pages: 249
Language: en
ISBN_13:9781461576617
ISBN_10:146157661X
Subject: Medical

Environmental Health Perspectives

Supplements

Free Epub

جزئیات و درخواست

1993
Pages: 628
Language: en
OTHER:UIUC:30112009349686
Subject: Carcinogenesis

EHP

Environmental Health Perspectives

Free Epub

جزئیات و درخواست

1993
Pages: 546
Language: en
OTHER:MINN:31951P00378591Z
Subject: Environmental health

Ecotoxicology and Genotoxicology

Non-traditional Aquatic Models

جزئیات و درخواست

By Marcelo L Larramendy
Publisher: Royal Society of Chemistry, 2017-07-05
Pages: 429
Language: en
ISBN_13:9781788011792
ISBN_10:1788011791
Subject: Science

Toxicology of Chemical Mixtures

Case Studies, Mechanisms, and Novel Approaches

جزئیات و درخواست

By Raymond S.H. Yang
Publisher: Elsevier, 2013-10-22
Pages: 745
Language: en
ISBN_13:9781483289403
ISBN_10:1483289400
Subject: Science

Ecotoxicity and Human Health

A Biological Approach to Environmental Remediation

جزئیات و درخواست

By Arthur D. Bloom, Frederick de Serres
Publisher: CRC Press, 1995-10-09
Pages: 340
Language: en
ISBN_10:1566701414
ISBN_13:9781566701419
Subject: Science

Technical Assistance Directory

Free Epub

جزئیات و درخواست

1991-07
Pages: 76
Language: en
OTHER:NYPL:33433059709174
Subject: Environmental protection

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