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تعداد نتایج: 195

Need-to-Know NAFLD

The Complete Guide to Nonalcoholic Fatty Liver Disease

By Naim Alkhouri, Stephen A. Harrison
Publisher: CRC Press, 2023-09-08
Pages: 556
Language: en
ISBN_13:9781000928662
ISBN_10:1000928667
Subject: Medical

Very Common Non-Alcoholic Fatty Liver Disease

How to Know If You Have Hepatic Steatosis

جزئیات و درخواست

By James M. Lowrance
Publisher: CreateSpace, 2013-10-18
Pages: 26
Language: en
ISBN_10:149352447X
ISBN_13:9781493524471
Subject: Health & Fitness

Non Alcoholic Fatty Liver Disease

All You Must Know

جزئیات و درخواست

By Dr Isreal Ogagaoghene
Publisher: Independently Published, 2020-03-07
Pages: 56
Language: en
ISBN_13:9798622434891

Nafld & Nash

The Definitive Guide for Patients with Fatty Liver Disease

جزئیات و درخواست

By Vanessa Linnett, David Jones Obe
Publisher: Independently Published, 2023-04-06
Language: en
ISBN_13:9798386791162

Fight Against Fatty Liver Cirrhosis

All That You Need to Know about Fatty Liver

جزئیات و درخواست

By Christine Howells
Publisher: Independently Published, 2019-12-03
Pages: 47
Language: en
ISBN_10:1671107187
ISBN_13:9781671107182

Fatty Liver Diet: Guide on How to End Fatty Liver Disease Fatty Liver Diet Books: Fatty Liver Diet

جزئیات و درخواست

By Charlie Mason
Publisher: Tilcan Group Limited, 2021-02-21
Pages: 74
Language: en
Subject: Medical

Loving Your Liver

Your Complete Guide to Prevent, Cure and Reverse Fatty Liver

جزئیات و درخواست

By Fhilcar Faunillan
Publisher: Createspace Independent Publishing Platform, 2015-12-25
Pages: 68
Language: en
ISBN_10:1523387599
ISBN_13:9781523387595

Non-Alcoholic Fatty Liver Disease

Aspects on Diagnosis and Long-term Prognosis

$Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease affecting approximately 25% of the global population and is commonly recognized as the hepatic manifestation of the metabolic syndrome. The histological spectrum of NAFLD ranges from isolated steatosis to non-alcoholic steatohepatitis (NASH), with risk of developing fibrosis and subsequent cirrhosis and hepatocellular carcinoma. The gold standard for diagnosing NAFLD is liver biopsy. However, because of its invasive nature, several non-invasive methods have been developed and validated in evaluating fat and fibrosis in patients with NAFLD. Liver fat content can be assessed using various methods. The conventional histopathological method consists of a visual semiquantitative approach in which the pathologist uses a four-point scale: grade 0 corresponds to fat deposition in <5% of hepatocytes and grade 1?3 (which is needed for the diagnosis of NAFLD) corresponds to ?5%. An alternate approach is to quantitatively assess steatosis using stereological point counting (SPC) – which rely on liver biopsy. However, in vivo proton magnetic resonance spectroscopy (1H-MRS) is a reliable noninvasive method that can be used to quantitatively assess total hepatic lipid content, or proton density fat fraction (PDFF). In Paper I we compared the conventional semiquantitative histological method (grade 0-3) with SPC and 1H-MRS. We found a strong positive correlation between 1H-MRS and SPC, whereas the correlations between 1H-MRS or SPC and histopathological grading were substantially weaker. Using the widely used cut-off value of PDFF ?5%, all participants were found to have steatosis (specificity 100%, sensitivity 53%). Reducing the cut-off value to 3% maintained 100% specificity while increasing sensitivity to 79%. In Paper IV we evaluated quantitative steatosis, by SPC, in 106 biopsy-proven NAFLD patients during a 20-year follow-up. SPC was independently associated with an increased risk of all-cause mortality and development of T2DM. Moreover, in the 59 patients with sequential biopsies (approximately 10 years apart), a reduction of quantitative hepatic steatosis decreased the all-time risk of developing T2DM. NASH is commonly seen as a histological feature portending a worse prognosis in NAFLD. Interestingly, no dual biopsy study has ever shown that NASH predicts fibrosis progression. Yet, NASH is seen as a surrogate marker in pharmaceutical trials – were resolution in NASH is equivalent to future resolution of fibrosis. In Paper II we conducted a long-term follow-up study (20 years) in a large cohort of biopsy-proven NAFLD patients (n=646), in a collaboration with Karolinska Institute. We could not ascertain that NASH had any effect on all-cause, or disease-specific mortality. However, higher stages of fibrosis predicted all-cause and disease specific mortality. In Paper III, we present 129 biopsy-proven NAFLD patients, in which we had prospective, longitudinal data. They were included between 1988 and 1993. All patients alive, were re-invited 2003-2005 and 2013-2015. Dual biopsies were present in 68 patients, and three consecutive biopsies were available in 33 patients. Results showed that NAFLD is a highly heterogeneous disease, with 9.3% developing end-stage liver disease and 16% progressing to advanced stages of fibrosis without any clinically significant baseline data predicting disease progression. In summary, when using 1H-MRS as a diagnostic method for NAFLD, the diagnostic cut-off should be reduced from 5% to 3%. Furthermore, quantitative amount of hepatic steatosis could be used to stratify patients with NAFLD related to future risk of developing T2DM. Moreover, we have shown that NASH does not predict future all-cause or disease-specific mortality nor end-stage liver disease, therefore a different surrogate marker should be used in clinical trials when assessing NAFLD improvement, so to not imbue false reliance in new therapies. Lastly, we have shown that NAFLD has a more dismal prognosis than previously reported, and that it is unexpectedly difficult to predict fibrosis progression in individual NAFLD patients, emphasizing the need for robust non-invasive biomarkers suitable to monitor large number of patients.$

جزئیات و درخواست

By Patrik Nasr
Publisher: Linköping University Electronic Press, 2019-09-25
Pages: 98
Language: en
ISBN_13:9789176850381
ISBN_10:9176850382

Fatty Liver Disease

The Ultimate Guide for Understanding the Fatty Liver Diet an...

جزئیات و درخواست

By Wade Migan
Publisher: CreateSpace, 2014-02-08
Pages: 56
Language: en
ISBN_10:1507876769
ISBN_13:9781507876763

Fatty Liver Antidote

The Definitive Guide on How to Diagnose, Prevent and Treat F...

جزئیات و درخواست

By Rowland Thomas
Publisher: Independently Published, 2019-10-19
Pages: 40
Language: en
ISBN_10:1701103028
ISBN_13:9781701103023

Beating Fatty Liver Disease

The Comprehensive Guide on Everything You Need to Know about...

جزئیات و درخواست

By Fred Wilson
2019-12-06
Pages: 30
Language: en
ISBN_10:1672368766
ISBN_13:9781672368766

Fatty Liver Diet

A 3-Week Step-by-Step Guide for Women Over 50

جزئیات و درخواست

By Stephanie Hinderock
Publisher: No Fluff Publishing , 2023-02-03
Pages: 44
Language: en
OTHER:PKEY:6610000436057
Subject: Health & Fitness

A Brief History of Fatty Liver Disease

How it Develops and Ways You Can Prevent It's Progression

جزئیات و درخواست

By Teresa Fikes
2021-03-09
Pages: 74
Language: en
ISBN_13:9798719541501

Reversing Your Non-Alcohol Fatty Liver Disease (NAFLD)

The 30 Day Journal for Raw Vegan Plant-Based Detoxification ...

جزئیات و درخواست

By Health Central
2019-10-29
Pages: 76
Language: en
ISBN_10:1703758552
ISBN_13:9781703758559

Fatty Liver Diet Cookbook

All You Need to Know about Fatty Liver Diet Includes Easy to...

جزئیات و درخواست

By Emily Green Rnd
2020-02-28
Pages: 66
Language: en
ISBN_13:9798619249064

Skinny Renal For Fatty Liver Disease Cure

A Proven Plan To Help Prevent And Reverse Fatty Liver Diseas...

جزئیات و درخواست

By Jennifer McBrown
2020-01-12
Pages: 86
Language: en
ISBN_10:1659331153
ISBN_13:9781659331158

Non-Alcoholic Fatty Liver Disease

A Practical Guide

جزئیات و درخواست

By Geoffrey C. Farrell, Arthur J. McCullough, Christopher P. Day
Publisher: John Wiley & Sons, 2013-04-29
Language: en
ISBN_10:0470673176
ISBN_13:9780470673171
Subject: Medical

Fatty Liver Diet for Dogs

Everything You Need To Know About Fatty Liver Diet for Dogs

جزئیات و درخواست

By Adam Scholes MD
2020-03-04
Pages: 36
Language: en
ISBN_13:9798621187927

CBD Oil for Nash Diseases

All You Need To Know About Using CBD OIL for Treating NASH D...

جزئیات و درخواست

By Aaron Wilmoore
2019-10-22
Pages: 84
Language: en
ISBN_10:1701875659
ISBN_13:9781701875654

Fatty Liver

The Ultimate Step-By-Step Guide to Understanding and Reversi...

جزئیات و درخواست

By Henry Thompson
Publisher: Createspace Independent Publishing Platform, 2017-06-14
Pages: 54
Language: en
ISBN_10:154728725X
ISBN_13:9781547287253

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