The Nobel Prize is by far the highest recognition a scientist may receive and the only one with which the general public is familiar. Its prestige has reached improbable heights. At the same time, a lot of myth surrounds the Nobel Prize, and this is compounded by the fact that people tend to view scientists with some bewilderment. This book introduces the process of selection of the laureates, discusses the ingredients for scientific discovery and for getting recognition. It reviews the decisive moments of scientific careers en route to the Nobel Prize, points to characteristic features of the laureates, the importance of mentors and venues in scientific careers and other components of success. It also covers some discoverers and discoveries for whom and for which the Nobel Prize never materialized.