Foreword: This book release, The Manual of Clinical Perfusion Second Edition Updated, is an update to the 1997 edition by John Brodie and Ronald Johnson. John & Ronald began this book project in 1994 and quickly developed what has become one of the most valuable publications for perfusionists, perfusion students and other perfusion-related medical professionals. As the new owners of this publication, we will do our best to preserve their concise and straight-forward format that has made this book so popular. As one might imagine, there have quite a few advances in perfusion technology in the last seven years. Vacuum assisted venous drainage, modified ultrafiltration and platelet-rich plasma sequestration are just a few that come mind. There has also been an agglomeration of new products released into the market including; oxygenators, cannulae, filters, medications and hardware devices. We have spent considerable time and effort revising and updating the contents to bring this manual up to date. Contents: Anatomy; Diagnostics; Blood; Blood Gases; Blood Disorders; Blood Conservation techniques; conduct of perfusion; Myocardial protection etc...