Carbohydrate Modifications in Antisense Research

• Author(s): Yogesh S. Sanghvi, American Chemical Society. Meeting,
• Publisher: American Chemical Society
• Pages: 232
• ISBN_10: 0841230560
  ISBN_13: 9780841230569
  
• Language: en
• Categories: Science / Life Sciences / Biochemistry , Science / Life Sciences / Botany , Science / Chemistry / Organic ,

Description:... Reviews recent developments and progress in the carbohydrate-related chemistry of novel nucleic acid mimics and their applications in antisense therapeutics. Discusses the use of new chemical classes to rationally design and synthesize oligonucleotides. Explores several carbohydrate modifications of the oligonucleotide to stabilize against nuclease degradation and to enhance the binding affinity for a given target. Suggests future directions of carbohydrate-related modifications for antisense molecules.