COVID-19 booster vaccination: increasing immunity against life-threatening infection
Description:... Although COVID-19 full prime vaccination generates immunity against severe and life-threatening infections, there are still cases of breakthrough infections. This might be due to several causes — such as the fact that full prime vaccination might not generate enough immunity; that immunity wanes over time; or that the elderly, immunocompromised, transplant recipients and people with underlying diseases could suffer severe infections regardless of vaccination. Moreover, emerging new variants of concern (such as Delta or Omicron) that are highly infective and evade immunity could increase breakthrough infection.
Booster shots could increase immunity and reduce the likelihood of having severe COVID and post-COVID-19 (long COVID). Immunocompromised or transplant recipients could generate immunity after booster shots even if they did not develop immunity after full prime. Moreover, booster shots not only protect vaccinated individuals, but they could also reduce the impact on lifestyle, public health and economics.
This research topic aims to focus on the effect of COVID-19 booster shots and the evidence seen in animal models, clinical trials, real-world evidence, and systematic reviews.
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