Drug Metabolizing Enzymes

Cytochrome P450 and Other Enzymes in Drug Discovery and Development

• Author(s): Jae Lee, R. Scott Obach, Michael B. Fisher,
• Publisher: Taylor & Francis
• Pages: 608
• ISBN_10: 0824742931
  ISBN_13: 9780824742935
  
• Language: en
• Categories: Medical / Pharmacology , Technology & Engineering / Chemical & Biochemical ,

Description:... Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.