Evaluation of Certain Veterinary Drug Residues in Food

Eighty-fifth Report of the Joint FAO/WHO Expert Committee on Food Additives

• Author(s): Joint FAO/WHO Expert Committee on Food Additives. Meeting, World Health Organization,
• Publisher: World Health Organization
• Pages: 150
• ISBN_10: 9241210176
  ISBN_13: 9789241210171
  
• Language: en
• Categories: Business & Economics / Reference , Cooking / General , Health & Fitness / Diet & Nutrition / Nutrition , Medical / Health Risk Assessment , Medical / Public Health , Medical / Veterinary Medicine / General , Medical / Toxicology , Social Science / Developing & Emerging Countries , Technology & Engineering / Food Science / General , Technology & Engineering / Food Science / Chemistry & Biotechnology , Technology & Engineering / Food Science / Food Safety & Security , Technology & Engineering / Food Science / Food Types ,

Description:... This report represents the conclusions of a Joint FAO/WHO Expert Committee convened in 2017 to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food.

The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including chronic dietary exposure assessment of compounds used as veterinary drugs and pesticides, assessment of the relative bioavailability and/or pharmacological activity of incurred drug residues in animal tissues, acute reference doses (ARfDs) for residues of veterinary drugs and methodological approaches and types of data for assessment of veterinary drug residues in food.

Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: three antimicrobial agents (amoxicillin, ampicillin and halquinol), an acaricide (ethion), an antiparasitic agent (flumethrin), an insecticide (lufenuron) and an anthelminthic (monepantel). In addition, the Committee considered issues raised by the Codex Committee on Residues of Veterinary Drugs in Foods concerning sisapronil, an ectoparasiticide, and zilpaterol hydrochloride, a ß2-adrenoceptor agonist. Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes (ADIs), ARfDs and proposed maximum residue limits (MRLs).