Assoziation des PDCD1 rs11568821 GG-Genotyps mit stärkerer Morbidität bei Intensivpatienten mit Krankheitsbild Sepsis
Vergleich der SOFA-Sub-Scores
Description:... The failing of various therapeutic agents in the treatment of sepsis elucidates the still existing lack of knowledge of this syndrome. Over the last years a major change has taken place as results have shown that, beside a cytokine-storm in an early hyper-inflammatory state, negative co-stimulatory receptors along with a late hypo-inflammatory state play a crucial role in the complex pathophysiology of sepsis. One of these receptors is PD-1, which is encoded by the gene PDCD1. The aim of this study was to illustrate whether a genetic predisposition (PDCD1 rs11568821 GG-genotype), which caus...
Show description