COX-2

A New Target for Cancer Prevention and Treatment

• Author(s): A. J. Dannenberg, R. N. DuBois, R. A. Stahel, S. Peters,
• Publisher: Karger Medical and Scientific Publishers
• Pages: 292
• ISBN_10: 3318009407
  ISBN_13: 9783318009408
  
• Language: en
• Categories: Medical / Chemotherapy , Medical / Clinical Medicine , Medical / Gastroenterology , Medical / Oncology / General , Medical / Pharmacology , Medical / Preventive Medicine , Medical / Public Health ,

Description:... Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.