The DNA Replication Machinery as Therapeutic Targets

• Author(s): Andrew F. Gardner, Zvi Kelman,
• Publisher: Frontiers Media SA
• Pages: 144
• ISBN_10: 2889459276
  ISBN_13: 9782889459278
  
• Language: en

Description:...

 In all organisms, the DNA replication machinery is responsible for accurate and

efficient duplication of the chromosome. Inhibitors of replication proteins are

commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA

Replication Machinery as Therapeutic Targets” examines the normal functions of

replication proteins as well as strategies to target each step during the replication

process including DNA unwinding, DNA synthesis, and DNA damage bypass and

repair. Articles discuss current strategies to develop drugs targeting DNA replication

proteins as well as future outlooks and needs.