“Immunotherapies against α-Synucleinopathies and Tauopathies”- Exploring the promising Disease-Modifying Treatment Strategies
Description:... “Immunotherapies against α-Synucleinopathies and Tauopathies”- Exploring the promising Disease-Modifying Treatment Strategies.,
α-Synuclein and tau deposition in the central nervous system is responsible for various parkinsonian syndromes, including:
§ Parkinson’s disease,
§ Multiple system atrophy,
§ Dementia with Lewy bodies,
§ Progressive supranuclear palsy and cortico-basal degeneration.
Emerging evidence has suggested that pathologic α-synuclein and tau are transmitted from cell to cell and further accelerate the aggregation of pathologic proteins in neighbouring cells.
Furthermore, extracellular pathologic proteins have also been reported to provoke inflammatory responses that lead to neurodegeneration.
Therefore, immunotherapies targeting extracellular α-synuclein and tau have been proposed as potential disease-modifying strategies.
It is strived in this E-BOOKLET to summarize completed phase I trials and ongoing phase II trials of immunotherapies against α-synuclein and tau and to discuss concerns and hurdles to overcome in the future.
Dr. H. K. Saboowala.
M.B.(Bom) .M.R.S.H.(London)
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