Interleukin-6-type Cytokines

• Author(s): Andrzej Mackiewicz, A. Koj, Pravinkumar B. Sehgal,
• Publisher: New York Academy of Sciences
• Pages: 522
• ISBN_10: 0897669312
  ISBN_13: 9780897669313
  
• Language: en
• Categories: Medical / Immunology , Medical / Physical Medicine & Rehabilitation ,

Description:... This volume discusses the role of interleukin-6-type cytokines in haematopoietic cell proliferation, neuronal differentiation and acute phase response to inflammation. New data is presented concerning the structure and function of interleukin-6, the leukemia inhibitory factor, interleukin-11, oncostatin M and the ciliary neurotrophic factor. Also discussed is cytokine receptor function, common signal transduction mechanisms, the molecular basis of cytokine-mediated alterations in gene expression, and regulation of cell proliferation. Pre-clinical and clinical studies with these cytokines are evaluated.