The Role of Wnt Signalling in the Development of Somites and Neural Crest

• Author(s): Corina Schmidt, Imelda McGonnell, Steve Allen, Ketan Patel,
• Publisher: Springer Science & Business Media
• Pages: 64
• ISBN_10: 354077727X
  ISBN_13: 9783540777274
  
• Language: en
• Categories: Medical / Neuroscience , Medical / General , Science / Life Sciences / Neuroscience , Medical / Research ,

Description:... (3) The intracellular response to Wnt signalling depends on the choice of signalling cascade activated in the responding cell. Recent work has identified the protein Naked Cuticle to act as an intracellular switch to promote the non-canonical pathway at the expense of the canonical pathway. The authors have cloned chick Naked Cuticle-1 and show that it is expressed in the somites and that the expression of cNkd1 is regulated by Wnt expression originating from the neural tube. This study provides evidence that non-canonical Wnt signalling plays a part in somite development.