Turner syndrome (TS) is a relatively common chromosomal disorder affecting
approximately 1 in 2000 live female births. Short stature is the most common clinical
presentation of the syndrome; it is observed in 80 % to 100 % of the girls with TS. Growth
is stunted to a variable degree at different phases of childhood and adolescence
in TS. Although there is consensus on treating growth failure as early as possible,
there is ongoing research to ameliorate final height in TS girls. The co-existence
of primary ovarian failure in girls with TS further complicates the management of
short stature. It remains to be determined what is the best age to begin treatment
for pubertal induction and/or maintenance of puberty; the best compound, dose,
or protocol to induce puberty. TS patients have increased mortality and morbidity
due to cardiovascular (CV) complications and multiple risk factors for ischaemic
heart disease, including hypertension, insulin resistance and dyslipidaemia. The CV
phenotype can be better assessed through identification of surrogate risk markers
and the relationship of these markers with TS - associated traits. There are very few
comprehensive studies on the dynamics of arterial tree and the associations of these
dynamics with influential factors in young TS patients. Deregulated signalling within
the GH-IGF1 axis may extend beyond the realm of physical stature in TS, resulting
in effects on the CV system and other organ systems. Although GH deficiency is
associated with CV risk, and excess of GH is also associated with increased CV risk.
Because TS patients receive supraphysiological doses of GH, there may be increased
risks for CV complications, although retrospective studies failed to document such
an association. There are still other unknown issues in the area of TS and CV issues
such as the definitions of “abnormal” aortic diameters, high blood pressure. There
is scarce data regarding how we can prevent catastrophic CV events in girls and
women with TS. There is a call for prospective studies regarding the pathogenesis,
diagnosis and prevention of CV disease in TS.TS patients usually have psychological
problems related to self-confidence and self-respect due to the high burden of
health-related issues they have to cope with at different stages of life. There remains
controversy on how to support them to accept their differences and empower them
to take an active role in their care. This e-book intends to provide insight on hot
topics of debate in TS. The e-book is subdivided into small sections to describe the content of the articles such as growth, puberty, cardiovascular issues, metabolic
issues, autoimmunity, cognitive and psychosocial issues to facilitate reading. We
hope it will serve as a reference tool for clinicians and researchers who are involved
in the diagnosis and management of females with TS.