Approaches to Advance Cancer Vaccines to Clinical Utility
Description:... Although cancer vaccines have yielded promising results both in vitro and in animal
models, their translation into clinical application has not been very successful so far.
Through the success of immune checkpoint inhibitors, the tumor immunotherapy
field revived and led to important new insights. A better understanding of the
functional capacity of different dendritic cell (DC) subsets and the immunogenicity
of tumor antigens, more particularly of neoantigens, have important implications
for the improvement of cancer vaccines. These insights can guide the development
of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of
this Research Topic is therefore to provide a comprehensive overview of current
issues regarding cancer vaccine development with an emphasis on novel approaches
toward enhancing their efficacy.
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