Recent Advances in Understanding The Genetics of Immunological Disorders
Description:... Immunological disorders are diseases or conditions due to the dysfunction of the immune system. They include primary immunodeficiency syndromes, autoimmune diseases, asthma, allergy, and autoinflammatory syndromes. These disorders disrupt our body’s ability to defend against pathogens. In addition, it may lead to exaggerated chronic inflammatory responses and tissue damage. Immunological disorders are clinically and genetically heterogeneous. The phenotypic spectrum of the diseases is broad in some of the disorders. On the other hand, the clinical phenotype derived from distinct genotypes can overlap, and the same phenotype can be cross-shared in different disorders. Therefore, accurate diagnosis and effective management are challenging.
Over the last decade, advances in genomics and sequencing platforms have accelerated the understanding of how candidate genes contribute to the development of immunological disorders. Significant progress has been made in discovering disease-causing genes for rare monogenic immunological disorders, especially in immunodeficiency syndrome. These findings shed insights into disease mechanisms and facilitated the identification of new biomarkers that can help in diagnosis, prognosis, and development of novel clinical therapeutic approaches.
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