PARP as a Therapeutic Target

• Author(s): Jei Zhang,
• Publisher: CRC Press
• Pages: 360
• ISBN_10: 104020032X
  ISBN_13: 9781040200322
  
• Language: en
• Categories: Medical / Pharmacology , Science / Chemistry / General , Science / Life Sciences / Cell Biology , Technology & Engineering / Chemical & Biochemical ,

Description:... Recent research in cell death mechanisms has rekindled interest in PARP's (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors' dual actions of preventing cell death and abating inflammati