برای ثبت درخواست به انتهای صفحه مراجعه کنید.

Cytotoxic Payloads for Antibody–Drug Conjugates

Description:...

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many.

The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity.

Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Show description

* ایمیل (آدرس Email را با دقت وارد کنید)
لینک پیگیری درخواست ایمیل می شود.
شماره تماس (ارسال لینک پیگیری از طریق SMS)
نمونه: 09123456789

در صورت نیاز توضیحات تکمیلی درخواست خود را وارد کنید

* تصویر امنیتی
 

به شما اطمینان می دهیم در کمتر از 8 ساعت به درخواست شما پاسخ خواهیم داد.

* نتیجه بررسی از طریق ایمیل ارسال خواهد شد

ضمانت بازگشت وجه بدون شرط
اعتماد سازی
انتقال وجه کارت به کارت
X

پرداخت وجه کارت به کارت

شماره کارت : 6104337650971516
شماره حساب : 8228146163
شناسه شبا (انتقال پایا) : IR410120020000008228146163
بانک ملت به نام مهدی تاج دینی

پس از پرداخت به صورت کارت به کارت، 4 رقم آخر شماره کارت خود را برای ما ارسال کنید.
X