Oxidative Stress, Inflammation and Atherosclerosis-Related Diseases: From basic to clinical research
Description:... Atherosclerosis can affect any artery in the body, including arteries in the heart, brain, arms, legs, pelvis, and kidneys. As a result, different diseases (ischemic heart disease, carotid artery disease, peripheral artery disease, ischemic stroke, and chronic kidney disease) may develop based on which arteries are affected.
Atherosclerosis-related diseases are a global crisis and require a global response. The increasing global crisis in atherosclerosis-related diseases is a barrier to development goals including poverty reduction, health equity, economic stability, and human security.
There is a synergic action between genetic, ambient, local, and systemic factors, and ultimately the progression of atherosclerosis is responsible for coronary heart disease (CHD) and its complications (such as unstable “in crescendo” angina, myocardial infarction, and sudden death), peripheral arterial disease, and ischemic stroke. Recent investigations show that mitochondrial alterations, oxidative stress and inflammation are inextricably linked and play major roles in the onset and development of atherosclerosis-related diseases. Long-term oxidative stress, autophagy and vascular inflammation could
lead to atherosclerosis-related diseases. The evidence of oxidative stress, inflammation, autophagy, mitochondrial dynamic dysfunction, and the interaction of those factors had been proposed.
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